Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

▪ Abstract Ena/VASP proteins are a conserved family of actin regulatory proteins made up of
EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Abstract The Wiskott–Aldrich syndrome protein (WASP) is an important regulator of the actin
cytoskeleton that is required for many haematopoietic and immune cell functions, including …

The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder with variable clinical
phenotypes that correlate with the type of mutations in the WAS protein (WASP) gene …

Protein–protein interactions occurring via the recognition of short peptide sequences by
modular interaction domains play a central role in the assembly of signalling protein …

One particularly abundant group of modular recognition domains consists of those that bind
proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a …

An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42
to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously …

The removal of the mRNA 5′ cap structure by the decapping enzyme DCP2 leads to rapid
5′→ 3′ mRNA degradation by XRN1, suggesting that the two processes are coordinated …