FinnTwin12 cohort: an updated review
This review offers an update on research conducted with FinnTwin12 (FT12), the youngest
of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage …
of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage …
Identical twins carry a persistent epigenetic signature of early genome programming
J van Dongen, SD Gordon, AF McRae… - Nature …, 2021 - nature.com
Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-
implantation stages of development. The mechanisms underpinning this event have …
implantation stages of development. The mechanisms underpinning this event have …
Co-twin design in brain imaging—review on biomarkers of Alzheimer's disease
A Varjonen, C Schwarz, E Vuoksimaa - Cerebral Cortex, 2023 - academic.oup.com
Twin samples allow to conduct a quasi-experimental co-twin case–control approach that can
control for genetic and environmental confounding in brain–cognition associations, being …
control for genetic and environmental confounding in brain–cognition associations, being …
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
BW van der Kolk, S Saari, A Lovric, M Arif… - Cell Reports …, 2021 - cell.com
Tissue-specific mechanisms prompting obesity-related development complications in
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …
BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index
S Lundgren, S Kuitunen, KH Pietiläinen… - Journal of Internal …, 2022 - Wiley Online Library
Background Obesity is a heritable complex phenotype that can increase the risk of age‐
related outcomes. Biological age can be estimated from DNA methylation (DNAm) using …
related outcomes. Biological age can be estimated from DNA methylation (DNAm) using …
Correlates and genetics of self‐reported sleep and awake bruxism in a nationwide twin cohort
J Ahlberg, M Piirtola, F Lobbezoo… - Journal of Oral …, 2020 - Wiley Online Library
Background Sleep bruxism (SB) and awake bruxism (AB) have been considered different
entities, although co‐occurrence between them has been shown. While genetic factors have …
entities, although co‐occurrence between them has been shown. While genetic factors have …
[HTML][HTML] Leisure-time and occupational physical activity associates differently with epigenetic aging
Purpose Greater leisure-time physical activity (LTPA) associates with healthier lives, but
knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA …
knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA …
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
H Mbarek, SD Gordon, DL Duffy, N Hubers… - Human …, 2024 - academic.oup.com
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
Higher dietary protein intake is associated with sarcopenia in older British twins
M Ni Lochlainn, RCE Bowyer, AA Welch… - Age and …, 2023 - academic.oup.com
Background Sarcopenia, characterised by an accelerated loss of skeletal muscle mass and
function, is associated with negative outcomes. This study aimed to evaluate factors …
function, is associated with negative outcomes. This study aimed to evaluate factors …
Metabolic syndrome and epigenetic aging: a twin study
T Föhr, A Hendrix, A Kankaanpää… - International Journal of …, 2024 - nature.com
Abstract Background Metabolic syndrome (MetS) is associated with premature aging, but
whether this association is driven by genetic or lifestyle factors remains unclear. Methods …
whether this association is driven by genetic or lifestyle factors remains unclear. Methods …