Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of …

The delicate microenvironment of the central nervous system (CNS) is protected by the
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …

Successful hematopoietic stem cell transplant requires the infusion of a sufficient number of
hematopoietic stem/progenitor cells (HSPCs) that are capable of homing to the bone marrow …

Polymorphonuclear neutrophils (PMNs) and monocyte/macrophages (MMs) are
professional phagocytic cells that are able to phagocytose and destroy infectious agents …

VCAM‐1 is one of the main ligands of VLA‐4, an integrin that is highly expressed on the
surface of mature B cells. Here we find that coexpression of VCAM‐1 on an antigen‐bearing …

Highlights•The ECM supports the HSC-supportive function of the bone marrow
microenvironment. microenvironment•The ECM provides a scaffold and serves as a source …

Neutrophil retention in and release from the bone marrow is a critical process that remains
incompletely understood. Previous work has implicated the CXCR4/stromal derived factor-1 …

Natalizumab antibody to α 4-integrins is used in therapy of multiple sclerosis and Crohn's
disease. A crystal structure of the Fab bound to an α 4 integrin β-propeller and thigh domain …

Intercellular adhesion mediated by integrin α 4 β 1 and vascular cell adhesion molecule-1
(VCAM-1) plays a crucial role in both the rolling and firm attachment of leukocytes onto the …

Integrins are cell adhesion receptors, expressed on every cell type, that have been
postulated to undergo conformational changes upon activation. Here, different affinity states …