[HTML][HTML] Inhalable nanoparticulate powders for respiratory delivery

P Muralidharan, M Malapit, E Mallory… - … , Biology and Medicine, 2015 - Elsevier
Nanoparticles are extensively studied for drug delivery and are proving to be effective in
drug delivery and the diagnostic field. Drug delivery to lungs has its advantages over other …

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers

R Pangeni, T Meng, S Poudel, D Sharma… - International journal of …, 2023 - Elsevier
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Spray-dried inhalable powder formulations of therapeutic proteins and peptides

BB Eedara, W Alabsi, D Encinas-Basurto, R Polt… - AAPS …, 2021 - Springer
Respiratory diseases are among the leading causes of morbidity and mortality worldwide.
Innovations in biochemical engineering and understanding of the pathophysiology of …

CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers

ZB Tong, B Zheng, RY Yang, AB Yu, HK Chan - Powder Technology, 2013 - Elsevier
This paper elucidates the important role of numerical technique in investigating powder
dispersion mechanisms in pharmaceutical dry powder inhalers, using the commercial …

Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled …

CW Park, X Li, FG Vogt, D Hayes Jr… - International journal of …, 2013 - Elsevier
Respirable microparticles/nanoparticles of the antibiotics vancomycin (VCM) and
clarithromycin (CLM) were successfully designed and developed by novel organic solution …

Dry powder inhalers in COPD, lung inflammation and pulmonary infections

P Muralidharan, D Hayes Jr… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: The number of pulmonary diseases that are effectively treated by aerosolized
medicine continues to grow. Areas covered: These diseases include chronic obstructive …

Mixing of dry powders for inhalation: A review

JE Spahn, F Zhang, HDC Smyth - International Journal of Pharmaceutics, 2022 - Elsevier
The process of solids mixing is applied across a considerable range of industries.
Pharmaceutical science is one of those industries that utilizes solids mixing extensively …

Formulation techniques for high dose dry powders

AD Brunaugh, HDC Smyth - International journal of pharmaceutics, 2018 - Elsevier
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the
treatment of both local pulmonary conditions and systemic diseases. Though DPIs are …

[图书][B] Drug delivery: fundamentals and applications

A Hillery, K Park - 2016 - taylorfrancis.com
This book provides a comprehensive introduction to advanced drug delivery and targeting,
covering their principles, current applications, and potential future developments. This …

Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and …

SA Meenach, FG Vogt, KW Anderson… - International journal …, 2013 - Taylor & Francis
Novel advanced spray-dried and co-spray-dried inhalable lung surfactant-mimic
phospholipid and poly (ethylene glycol)(PEG) ylated lipopolymers as microparticulate …