Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

1 The effectiveness of antimuscarinic agents in the treatment of the overactive bladder (OAB)
syndrome is thought to arise through blockade of bladder muscarinic receptors located on …

For many years, antimuscarinic drugs have been the first-line pharmacological treatment for
urgency, frequency, and urge incontinence, all symptoms of the disorder termed overactive …

The pharmacological treatment of urinary incontinence Page 1 BJU International (1999), 84,
923–947 REVIEW The pharmacological treatment of urinary incontinence K.-E …

Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

OBJECTIVES: To investigate the effects of darifenacin controlled-release (CR) and
oxybutynin extended-release (ER) on cognitive function (particularly memory) in older …

Muscarinic receptor antagonists (antimuscarinics) serve as the cornerstone in the
pharmacological management of overactive bladder (OAB) by relieving the symptoms of …

Contraction of the bladder, voluntary or involuntary, involves stimulation of the muscarinic
receptors on the detrusor by acetylcholine, released from activated cholinergic nerves …

BACKGROUND: Pharmacotherapy constitutes an important adjunct to behavioral therapy for
the treatment of overactive bladder (OAB). Tolterodine and oxybutynin are commonly …

We investigated muscarinic receptors in the detrusor and mucosa of the human bladder
body. Radioligand-binding studies with [3 H] QNB were conducted using specimens …