Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications
Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought
about some beneficial effects on improving the therapeutic outcomes of cell therapy and …
about some beneficial effects on improving the therapeutic outcomes of cell therapy and …
Endothelial progenitor cells in the host defense response
X Shi, KA Seidle, KJ Simms, F Dong, WM Chilian… - Pharmacology & …, 2023 - Elsevier
Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …
[HTML][HTML] Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis
J Asai, H Takenaka, S Hirakawa, J Sakabe… - The American journal of …, 2012 - Elsevier
Impaired wound healing is a major complication of diabetes. Recent studies have reported
reduced lymphangiogenesis and angiogenesis during diabetic wound healing, which are …
reduced lymphangiogenesis and angiogenesis during diabetic wound healing, which are …
Paracrine action of mesenchymal stem cells revealed by single cell gene profiling in infarcted murine hearts
Background Mesenchymal stem cells (MSCs) have been recently demonstrated as a
promising stem cell type to rescue damaged myocardium after acute infarction. One of the …
promising stem cell type to rescue damaged myocardium after acute infarction. One of the …
Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats
HI Ammar, AM Shamseldeen… - American Journal …, 2021 - journals.physiology.org
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated potential in
treating diabetic cardiomyopathy. However, patients with diabetes are on multiple drugs and …
treating diabetic cardiomyopathy. However, patients with diabetes are on multiple drugs and …
The balance between induction and inhibition of mevalonate pathway regulates cancer suppression by statins: A review of molecular mechanisms
Y Ahmadi, A Ghorbanihaghjo, H Argani - Chemico-biological interactions, 2017 - Elsevier
Statins are widely used drugs for their role in decreasing cholesterol in
hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA …
hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA …
Simvastatin accelerates the healing process of burn wound in Wistar rats through Akt/mTOR signaling pathway
P Ramhormozi, JM Ansari, S Simorgh… - Annals of Anatomy …, 2021 - Elsevier
Statins, apart from cholesterol-lowering properties, have wound healing effects. Hereby, we
aimed to assess the impact of Simvastatin (SMV), one of the most commonly used statins, on …
aimed to assess the impact of Simvastatin (SMV), one of the most commonly used statins, on …
Effect of atorvastatin on angiogenesis-related genes VEGF-A, HGF and IGF-1 and the modulation of PI3K/AKT/mTOR transcripts in bone-marrow-derived …
A Adamičková, N Chomaničová, A Gažová… - Current Issues in …, 2023 - mdpi.com
Stem cell transplantation represents a unique therapeutic tool in tissue engineering and
regenerative medicine. However, it was shown that the post-injection survival of stem cells is …
regenerative medicine. However, it was shown that the post-injection survival of stem cells is …
Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury
J Cai, X Yu, B Zhang, H Zhang, Y Fang, S Liu… - American journal of …, 2014 - karger.com
Aims: To investigate the impacts of combinatorial atorvastatin (Ator) perioperative
administration and mesenchymal stem cell (MSC) implantation on therapeutic effects in the …
administration and mesenchymal stem cell (MSC) implantation on therapeutic effects in the …
Stem cell-derived exosomes: Role in the pathogenesis and treatment of atherosclerosis
H Ling, Z Guo, L Tan, Q Cao, C Song - The International Journal of …, 2021 - Elsevier
Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by the
accumulation of lipids and inflammatory debris in large arteries, high morbidity, and AS …
accumulation of lipids and inflammatory debris in large arteries, high morbidity, and AS …