A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia
EH Simpson, C Kellendonk, E Kandel - Neuron, 2010 - cell.com
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are
thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused …
thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused …
Molecular mechanisms of schizophrenia
Schizophrenia is a complex disorder, where family, twin and adoption studies have been
demonstrating a high heritability of the disease and that this disease is not simply defined by …
demonstrating a high heritability of the disease and that this disease is not simply defined by …
Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
LF Wockner, EP Noble, BR Lawford… - Translational …, 2014 - nature.com
Recent studies suggest that genetic and environmental factors do not account for all the
schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA …
schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA …
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
C Kellendonk, EH Simpson, HJ Polan, G Malleret… - Neuron, 2006 - cell.com
Increased activity of D2 receptors (D2Rs) in the striatum has been linked to the
pathophysiology of schizophrenia. To determine directly the behavioral and physiological …
pathophysiology of schizophrenia. To determine directly the behavioral and physiological …
Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes
and brain disorders, but the effect of DRD2 variants remains ambiguous. We measured …
and brain disorders, but the effect of DRD2 variants remains ambiguous. We measured …
Psychosis pathways converge via D2High dopamine receptors
P Seeman, J Schwarz, JF Chen, H Szechtman… - Synapse, 2006 - Wiley Online Library
The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with …
sensitivity that is common to the many animal models of human psychoses associated with …
Dopamine D2 receptors as treatment targets in schizophrenia
P Seeman - Clinical schizophrenia & related psychoses, 2010 - meridian.allenpress.com
The antipsychotic effectiveness of chlorpromazine and haloperidol started a search for their
therapeutic targets. The antipsychotic receptor target turned out to be a dopamine receptor …
therapeutic targets. The antipsychotic receptor target turned out to be a dopamine receptor …
Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse
The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental
disorders and cocaine abuse, but mechanisms responsible for this relationship remain …
disorders and cocaine abuse, but mechanisms responsible for this relationship remain …
[HTML][HTML] G protein-coupled receptors in major psychiatric disorders
LA Catapano, HK Manji - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
Although the molecular mechanisms underlying psychiatric illnesses such as depression,
bipolar disorder and schizophrenia remain incompletely understood, there is increasing …
bipolar disorder and schizophrenia remain incompletely understood, there is increasing …
Modeling cognitive endophenotypes of schizophrenia in mice
C Kellendonk, EH Simpson, ER Kandel - Trends in neurosciences, 2009 - cell.com
Schizophrenia is a complex mental disorder that is still characterized by its symptoms rather
than by biological markers because we have only a limited knowledge of its underlying …
than by biological markers because we have only a limited knowledge of its underlying …