Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus

V Vasilkov, B Caswell-Midwinter, Y Zhao… - Scientific Reports, 2023 - nature.com
Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

Cutting through the noise: Noise-induced cochlear synaptopathy and individual differences in speech understanding among listeners with normal audiograms

M DiNino, LL Holt, BG Shinn-Cunningham - Ear and hearing, 2022 - journals.lww.com
Following a conversation in a crowded restaurant or at a lively party poses immense
perceptual challenges for some individuals with normal hearing thresholds. A number of …

Prevention of noise-induced hearing loss using investigational medicines for the inner ear: Previous trial outcomes should inform future trial design

CG Le Prell - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Noise-induced hearing loss (NIHL) is an important public health issue resulting
in decreased quality of life for affected individuals, and significant costs to employers and …

Predicting neural deficits in sensorineural hearing loss from word recognition scores

KJ Grant, A Parthasarathy, V Vasilkov… - Scientific reports, 2022 - nature.com
The current gold standard of clinical hearing assessment includes a pure-tone audiogram
combined with a word recognition task. This retrospective study tests the hypothesis that …

[HTML][HTML] Isolating auditory-nerve contributions to electrocochleography by high-pass filtering: A better biomarker for cochlear nerve degeneration?

V Vasilkov, MC Liberman, SF Maison - JASA Express Letters, 2023 - pubs.aip.org
In search of biomarkers for cochlear neural degeneration (CND) in electrocochleography
from humans with normal thresholds, we high-pass and low-pass filtered the responses to …

[HTML][HTML] A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept

AC Foster, S Szobota, F Piu, BE Jacques… - The Journal of the …, 2022 - pubs.aip.org
Currently, there are no approved medicines available for the treatment of hearing loss.
However, research over the past two decades has contributed to a growing understanding of …

Audiological and psychological assessment of tinnitus patients with normal hearing

Y Park, SH Shin, SW Byun, ZY Lee, HY Lee - Frontiers in Neurology, 2023 - frontiersin.org
Introduction This study was performed to assess identifiable abnormalities in tinnitus
patients with normal hearing. Methods The medical records of subjective non-pulsatile …

The middle ear muscle reflex: Current and future role in assessing noise-induced cochlear damage

M Trevino, A Zang, E Lobarinas - The Journal of the Acoustical Society …, 2023 - pubs.aip.org
The middle ear muscle reflex (MEMR) in humans is a bilateral contraction of the middle ear
stapedial muscle in response to moderate-to-high intensity acoustic stimuli. Clinically …

Envelope following responses for hearing diagnosis: Robustness and methodological considerations

H Van Der Biest, S Keshishzadeh, H Keppler… - The Journal of the …, 2023 - pubs.aip.org
Recent studies have found that envelope following responses (EFRs) are a marker of age-
related and noise-or ototoxic-induced cochlear synaptopathy (CS) in research animals …

Hidden hearing loss: Fifteen years at a glance

J Liu, J Stohl, T Overath - Hearing Research, 2024 - Elsevier
Hearing loss affects approximately 18% of the population worldwide. Hearing difficulties in
noisy environments without accompanying audiometric threshold shifts likely affect an even …