Gene therapy using haematopoietic stem and progenitor cells

G Ferrari, AJ Thrasher, A Aiuti - Nature Reviews Genetics, 2021 - nature.com
Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

The evolving view of thermogenic adipocytes—ontogeny, niche and function

F Shamsi, CH Wang, YH Tseng - Nature Reviews Endocrinology, 2021 - nature.com
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Rolling circle amplification (RCA)-based DNA hydrogel

C Yao, R Zhang, J Tang, D Yang - Nature protocols, 2021 - nature.com
DNA hydrogels have unique properties, including sequence programmability, precise
molecular recognition, stimuli-responsiveness, biocompatibility and biodegradability, that …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids

D Hendriks, H Clevers, B Artegiani - Cell stem cell, 2020 - cell.com
CRISPR-Cas technology has revolutionized biological research and holds great therapeutic
potential. Here, we review CRISPR-Cas systems and their latest developments with an …

[HTML][HTML] Current state of stem cell-based therapies: an overview

RM Aly - Stem cell investigation, 2020 - ncbi.nlm.nih.gov
Recent research reporting successful translation of stem cell therapies to patients have
enriched the hope that such regenerative strategies may one day become a treatment for a …

Cell‐based delivery systems: emerging carriers for immunotherapy

Z Li, Y Wang, Y Ding, L Repp… - Advanced Functional …, 2021 - Wiley Online Library
Immunotherapy is leading a paradigm shift in the treatment of various diseases, including
tumors, auto‐immune diseases, and infectious diseases. However, the limited response rate …

DNA supramolecular assembly on micro/nanointerfaces for bioanalysis

C Yao, J Ou, J Tang, D Yang - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Facing increasing demand for precision medicine, materials chemistry systems
for bioanalysis with accurate molecular design, controllable structure, and adjustable …

Double rolling circle amplification generates physically cross-linked DNA network for stem cell fishing

C Yao, H Tang, W Wu, J Tang, W Guo… - Journal of the …, 2020 - ACS Publications
Stem cells have been widely studied in cell biology and utilized in cell-based therapies, and
fishing stem cells from marrow is highly challenging due to the ultralow content. Herein, a …

[HTML][HTML] Advances in regenerative therapy: A review of the literature and future directions

EH Ntege, H Sunami, Y Shimizu - Regenerative therapy, 2020 - Elsevier
There is enormous global anticipation for stem cell-based therapies that are safe and
effective. Numerous pre-clinical studies present encouraging results on the therapeutic …