Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …