Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …

Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued
humanity for centuries and has claimed numerous lives across the globe. Concerted efforts …

Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major
cause of morbidity and mortality worldwide. Slow progress has been made in lessening the …

Background: The diversity and composition of the gut microbiota may affect breast cancer
risk by modulating systemic levels of oestrogens and inflammation. The current investigation …

Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

A major constraint for developing new anti-tuberculosis drugs is the limited number of
validated targets that allow eradication of persistent infections. Here, we uncover a …

Humans serve as both host and reservoir for Mycobacterium tuberculosis, making
tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between …

Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each
year, is typically characterized by the formation of tuberculous granulomas—the …

Metabolomics is an emerging and promising omics approach used to understand biological
mechanisms. By untargeted and targeted metabolomics analyses, metabolites are …

Methionine and cysteine metabolisms are important for the survival and pathogenesis of
Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to …