The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit
signals from their receptors to regulate gene expression and prevent apoptosis. Some …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …

The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of
various cellular processes such as proliferation, differentiation, development, learning …

Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome
16p11. 2 have been implicated in childhood-onset developmental disorders,,. We report the …

ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

Background Deletion and the reciprocal duplication in 16p11. 2 were recently associated
with autism and developmental delay. Method We indentified 27 deletions and 18 …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …