HIV-1 adaptation to HLA: a window into virus–host immune interactions
HIV-1 develops specific mutations within its genome that allow it to escape detection by
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
Nef proteins from HIV-1 elite controllers are inefficient at preventing antibody-dependent cellular cytotoxicity
Impairment of Nef function, including reduced CD4 downregulation, was described in a
subset of HIV-1-infected individuals that control viral replication without antiretroviral …
subset of HIV-1-infected individuals that control viral replication without antiretroviral …
Attenuation of multiple Nef functions in HIV-1 elite controllers
P Mwimanzi, TJ Markle, E Martin, Y Ogata, XT Kuang… - Retrovirology, 2013 - Springer
Abstract Background Impaired HIV-1 Gag, Pol, and Env function has been described in elite
controllers (EC) who spontaneously suppress plasma viremia to< 50 RNA copies/mL; …
controllers (EC) who spontaneously suppress plasma viremia to< 50 RNA copies/mL; …
Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural …
HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia,
progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in …
progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in …
Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase–integrase sequences from HIV-1 elite controllers
ZL Brumme, C Li, T Miura, J Sela… - JAIDS Journal of …, 2011 - journals.lww.com
Background: Identifying viral and host determinants of HIV-1 elite control may help inform
novel therapeutic and/or vaccination strategies. Previously, we observed decreased …
novel therapeutic and/or vaccination strategies. Previously, we observed decreased …
Differential clade-specific HLA-B* 3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope
PC Matthews, M Koyanagi, HN Kløverpris… - Journal of …, 2012 - Am Soc Microbiol
The strongest genetic influence on immune control in HIV-1 infection is the HLA class I
genotype. Rapid disease progression in B-clade infection has been linked to HLA-B* 35 …
genotype. Rapid disease progression in B-clade infection has been linked to HLA-B* 35 …
Impaired downregulation of NKG2D ligands by Nef proteins from elite controllers sensitizes HIV-1-infected cells to antibody-dependent cellular cytotoxicity
ABSTRACT HIV-1 Nef clones isolated from a rare subset of HIV-1-infected elite controllers
(EC), with the ability to suppress viral load to undetectable levels in the absence of …
(EC), with the ability to suppress viral load to undetectable levels in the absence of …
Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic
LA Cotton, XT Kuang, AQ Le, JM Carlson, B Chan… - PLoS …, 2014 - journals.plos.org
HLA-restricted immune escape mutations that persist following HIV transmission could
gradually spread through the viral population, thereby compromising host antiviral immunity …
gradually spread through the viral population, thereby compromising host antiviral immunity …
Impaired Nef function is associated with early control of HIV-1 viremia
XT Kuang, X Li, G Anmole, P Mwimanzi… - Journal of …, 2014 - Am Soc Microbiol
Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been
observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of …
observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of …
Differential ability of primary HIV-1 Nef isolates to downregulate HIV-1 entry receptors
M Toyoda, Y Ogata, M Mahiti, Y Maeda… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors
CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral …
CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral …