The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …

Many signaling pathways are dysregulated in cancer cells and the host tumor
microenvironment. Aberrant receptor tyrosine kinase (RTK) pathways promote cancer …

Hsp90 is a chaperone protein that interacts with client proteins that are known to be in the
cell cycle, signaling and chromatin-remodeling pathways. Hsp90 inhibitors act additively or …

Malignant mesothelioma (MM) is a relatively rare but devastating tumor that is increasing
worldwide. Yet, because of difficulties in early diagnosis and resistance to conventional …

Context.—In recent decades, research on malignant pleural mesothelioma (MPM) has been
developed to improve patients' outcomes by increasing the level of confidence in MPM …

Background Mutational inactivation of the SETDB1 histone methyltransferase is found in a
subset of mesothelioma, particularly in cases with near-haploidy and TP53 mutations …

Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to
promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several …

Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident
in the dismal overall survival for patients with those of asbestos-associated disease. We …

Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been
associated with tumor progression in a wide variety of human malignancies, notably in …

The term molecular chaperone was first used to describe the ability of nucleoplasmin to
prevent the aggregation of histones with DNA during the assembly of nucleosomes …