Multiple forms of regulated cell death (RCD) have been characterized, each of which
originates from the activation of a dedicated molecular machinery. RCD can occur in purely …

Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy,
which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …

Restoring apoptotic cell death is a critical goal for cancer therapy. One of the primary
mechanisms by which cancer cells evade death and maintain survival in the face of stress …

Cellular senescence occurs in response to endogenous or exogenous stresses and is
characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of …

BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC).
Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) …

Chemotherapy resistance is the major cause of treatment failure in osteosarcoma, the most
common primary bone malignancy, and sensitizing therapeutic strategy is required to …

Artificial intelligence (AI) platforms, such as Generative Pretrained Transformer (ChatGPT),
have achieved a high degree of popularity within the scientific community due to their utility …

Several breakthrough articles have recently confirmed the ability of tumor cells to escape the
stable cell cycle arrest imposed by Therapy-Induced Senescence (TIS). Subsequently …

Therapy-related myeloid neoplasms (t-MN) arise after a documented history of
chemo/radiotherapy as treatment for an unrelated condition and account for 10–20% of …

Aims: More effective treatment options for patients with renal cell carcinoma (RCC) are
needed, in particular advanced RCC. Background: Sunitinib, a multitarget tyrosine kinase …