Cell-based cardiac repair offers the promise of rebuilding the injured heart from its
component parts. Work began with committed cells such as skeletal myoblasts, but recently …

Driven by enormous clinical need, myocardial tissue engineering has become a prime focus
of research within the field of tissue engineering. Myocardial tissue engineering combines …

Background—Systemic delivery of bone marrow–derived mesenchymal stem cells (BM-
MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat …

Background Myocardial regeneration via stem-cell mobilisation at the time of myocardial
infarction is known to occur, although the mechanism for stem-cell homing to infarcted tissue …

Cardiac tissue engineering is an emerging field. The suitability of engineered heart tissue
(EHT) for both in vitro and in vivo applications will depend on the degree of syncytoid tissue …

Cell replacement therapy is a promising approach for the treatment of cardiac diseases, but
is challenged by a limited supply of appropriate cells. We have investigated whether …

The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost
cells. Therefore, the heart is a major target of research within the field of tissue engineering …

Cell therapy is emerging as a promising strategy for myocardial repair. This approach is
hampered, however, by the lack of sources for human cardiac tissue and by the absence of …

Objectives: We evaluated the ability of human embryonic stem cells (hESCs) and their
cardiomyocyte derivatives (hESC-CMs) to engraft and improve myocardial performance in …

Background—Adverse cardiac remodeling and progression of heart failure after myocardial
infarction are associated with excessive and continuous damage to the extracellular matrix …