Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a
variety of cardiac pathologies, including cardiac failure and those related to …

Since its description in myocardial ischemia/reperfusion a decade ago, the process of
programmed cell death has been the subject of intense study by investigators in cardiology …

Many of the originally identified cardiovascular 'growth factors' have been demonstrated to
exert a diverse variety of actions within the cardiovascular system, the majority of which are …

Urocortin 1, a human homologue of fish urotensin I, together with its related-compounds
(urocortins 2 and 3), comprises a distinct family of stress peptides. Urocortin 1 has a high …

Both calcium-independent phospholipase A2 beta (iPLA2β) and endoplasmic reticulum
(ER) stress regulate important pathophysiological processes including inflammation …

Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and
chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 …

Urocortin (UCN) protects hearts against ischemia and reperfusion injury whether given
before ischemia or at reperfusion. Here we investigate the roles of PKC, reactive oxygen …

Doxorubicin (DOX) is widely used against cancer but carries the risk of a progressive
cardiomyopathy. Astragalus polysaccharides (ASP) is the main active ingredient of …

Urocortin has been shown to produce vasodilatation in several arteries, but the precise
mechanism of its action is still poorly understood. Here we demonstrate the role of store …