Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

A variety of species of bacteria are known to colonize human tumours,,,,,,,,,–, proliferate
within them and modulate immune function, which ultimately affects the survival of patients …

Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …

The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

Although considered to be an extracellular pathogen, Staphylococcus aureus is able to
invade a variety of mammalian, non-professional phagocytes and can also survive …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a
biochemical mediator of stimuli as diverse as ionizing radiation, chemotherapy, UVA light …