Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their
diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is …

Background A number of biomarkers have been studied for the diagnosis of sepsis in
paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated …

Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first
72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up …

Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an
infection resulting in multiple organ dysfunctions. Early diagnosis and management of …

The vulnerability to infection of newborns is associated with a limited ability to mount efficient
immune responses. High concentrations of adenosine and prostaglandins in the fetal and …

Objective: The burn victim's inherent state of hyperinflammation frequently camouflages
septic events delaying the initiation of targeted intensive care therapy. Accurate biomarkers …

Identifying febrile children at risk of sepsis in low-resource settings can improve survival, but
recognition triage tools are lacking. Here we test the hypothesis that measuring circulating …

Background: Early onset sepsis (EOS) remains a major cause of mortality and morbidity in
neonates, and traditional clinical markers effective for adults are less effective in these …

Background Elevated C-reactive protein (CRP) level is widely used in clinical practice as a
marker to distinguish between neonates with or without sepsis. However, some neonates …

Background Infections are leading causes of morbidity and mortality in neonates and may
also have severe long-term consequences. As early diagnosis of neonatal sepsis improves …