The molecular characterization of poorly and anaplastic thyroid carcinomas has been
greatly improved in the last years following the advent of high throughput technologies …

The transcriptional de-repression of the telomerase reverse transcriptase (TERT) gene and
subsequent activation of telomerase is a prerequisite step in malignant transformation and …

Aims DICER1 germline mutations cause DICER1 syndrome, in which multinodular goitre is
a common feature. Recently, somatic DICER1 mutations have been reported in sporadic …

Follicular-patterned tumors of the thyroid in the adult population frequently harbor RAS
mutations or PAX8-PPARG rearrangement, but little is known about molecular profiles in the …

DICER1 gene encodes an RNaseIII endoribonuclease essential for the cleavage of pre-
microRNA to mature microRNA. Germline DICER1 mutation results in DICER syndrome, a …

Background The genomic and transcriptomic landscape of widely invasive follicular thyroid
carcinomas (wiFTCs) and Hürthle cell carcinoma (HCC) are poorly characterized, and …

Mutational inactivation of the DICER1 gene causes aberrant micro-RNA maturation, which in
turn may have consequences for the posttranscriptional regulation of gene expression …

Background Mutations in micro-RNA (miRNA) regulators DICER1 and DGCR8 have recently
been uncovered, revealing a potential novel mechanism driving thyroid tumor development …

Introduction DICER1 mutated thyroid nodules are commonly seen in pediatric populations
often, as part of DICER1 syndrome. We seek to evaluate DICER1 mutated thyroid nodules in …

Background. GA‐binding protein A (GABPA), a transcription factor, is broadly involved in
physiological and pathological processes. Several studies have investigated the …