Gastric cancer is still an important disease causing many deaths worldwide, although there
has been a marked reduction in prevalence during the last few decades. The decline in …

Recent milestones in the understanding of gastric acid secretion and treatment of acid-
peptic disorders include the (1) discovery of histamine H2-receptors and development of …

Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better
knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

Background Proton pump inhibitors (PPI s) are potent inhibitors of gastric acid secretion and
give hypergastrinemia secondary to gastric hypoacidity. PPI treatment therefore induces …

Neuroendocrine tumors (NETs) throughout the body are the focus of much current interest.
Most occur in the gastrointestinal tract and have shown a major increase in incidence over …

Background Patients with chronic atrophic gastritis have long‐term gastric hypoacidity, and
secondary hypergastrinaemia. Some also develop gastric ECL cells carcinoids (type 1 GC) …

We continue to make progress in our understanding of the regulation of gastric acid
secretion in health and disease. A better understanding of the pathways and mechanisms …

Background: Rebound acid hypersecretion develops after the use of acid inhibitors. Aim: To
estimate the duration of hypersecretion and to elucidate the role of the enterochromaffin‐like …