In the last decade, network approaches have transformed our understanding of biological
systems. Network analyses and visualizations have allowed us to identify essential …

Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth
and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an …

High-throughput screening and gene signature analyses frequently identify lead therapeutic
compounds with unknown modes of action (MoAs), and the resulting uncertainties can lead …

For decades, molecular biologists have been uncovering the mechanics of biological
systems. Efforts to bring their findings together have led to the development of multiple …

High-throughput RNAi screenings (HTS) allow quantifying the impact of the deletion of each
gene in any particular function, from virus-host interactions to cell differentiation. However …

Motivation Functional genomics experiments generate genomewide signal profiles that are
dense information sources for annotating the regulatory elements. These profiles measure …

As next generation sequencing technologies continue to mature and find applications
across genomics, it has become clear that the scale and scope of generated data far …

L'analyse de la transcription des gènes à grande échelle est la clé de voûte de la
compréhension de leur fonction et de la fonction des protéines qu'elles traduisent. Elle a …