In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Given that cancer mortality is usually a result of late diagnosis, efforts in the field of early
detection are paramount to reducing cancer-related deaths and improving patient outcomes …

Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of
residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific …

Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die,
partly because they experience oxidative stress. Metastasizing cancer cells migrate through …

Necrosis in the tumor interior is a common feature of aggressive cancers that is associated
with poor clinical prognosis and the development of metastasis. How the necrotic core …

Metastasis formation is the main cause of cancer-related death in patients with solid
tumours. At the beginning of this process, cancer cells escape from the primary tumour to the …