Large-scale multi-omics datasets, most prominently from the TCGA consortium, have been
made available to the public for systematic characterization of human cancers. However, to …

Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …

Cancer has been constantly evolving and so is the research pertaining to cancer diagnosis
and therapeutic regimens. Early detection and specific therapeutics are the key features of …

Simple Summary Krüppel-like Factor-9 (KLF9) and Krüppel-like Factor-13 (KLF13) are
highly related proteins that function as inducers and/or repressors of specific target gene …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation
from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases …

DNA methylation is known to be the most stable epigenetic modification and has been
extensively studied in relation to cell differentiation, development, X chromosome …

DNA methylation plays a crucial role in tumorigenesis and tumor progression, sparking
substantial interest in the clinical applications of cancer DNA methylation biomarkers …

T cell leukemia homeobox 2 (TLX2) plays an important role in some tumors. Bioinformatics
and experimental validation represent a useful way to explore the mechanisms and …

Purpose To examine the expression, clinical significance, and potential regulatory
mechanism of centromere protein O (CENPO) in hepatocellular carcinoma (HCC). Methods …

Abstract Benzo [a] pyrene (BaP) exposure has been associated with an increased risk of
carcinogenesis. We investigated the effects of BaP on cell viability, the promoter methylation …