Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …

Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been
reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase …

The discovery of the highly efficient site-specific nuclease system CRISPR–Cas9 from
Streptococcus pyogenes has galvanized the field of gene therapy,. The immunogenicity of …

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

Pulmonary hypertension is a substantial global health issue. All age groups are affected with
rapidly growing importance in elderly people, particularly in countries with ageing …

There is a global commitment to reduce premature cardiovascular diseases (CVDs) 25% by
2025. CVD mortality rates have declined dramatically over the past 2 decades, yet the …

Background Donor-specific antibodies create an immunologic barrier to transplantation.
Current therapies to modify donor-specific antibodies are limited and ineffective in the most …

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused
by infection with group A Streptococcus. The long-term damage to cardiac valves caused by …