Tipping points in complex systems may imply risks of unwanted collapse, but also
opportunities for positive change. Our capacity to navigate such risks and opportunities can …

Highlights•Principal Component Analysis provides a general frame for systemic approaches
in pharmacology.•Principal components correspond to the latent factors of a data …

In this paper, we characterize major depression (MD) as a complex dynamic system in which
symptoms (eg, insomnia and fatigue) are directly connected to one another in a network …

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

The concept of biological adaptation was closely connected to some mathematical,
engineering and physical ideas from the very beginning. Cannon in his “The wisdom of the …

Abstract The “Law of the Minimum” states that growth is controlled by the scarcest resource
(limiting factor). This concept was originally applied to plant or crop growth (Justus von …

The literature on psychotherapy research makes use of the so-called" Dodo Bird Verdict" to
show that therapeutic change owes more to common factors than to specific techniques …

Aims of this study were: to verify if Recurrence Quantification Analysis (RQA) of Heart Rate
Variability (HRV) time series could determine both ventilatory thresholds in individuals with …

Abstract Systems healthcare is a holistic approach to health premised on systems biology
and medicine. The approach integrates data from molecules, cells, organs, the individual …

Heart rate time series are widely used to characterize physiological states and athletic
performance. Among the main indicators of metabolic and physiological states, the detection …