Optimizing the prescription of antimicrobials is required to improve clinical outcome from
infections and to reduce the development of antimicrobial resistance. One such method to …

Antimicrobial agents, especially antibacterial agents, are used throughout the world, across
a diverse array of extensive and intensive livestock production systems, to protect the health …

The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …

Introduction In the time of increasing resistance and paucity of new drug development there
is a growing need for strategies to enhance rational use of antibiotics in German and …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

High mortality and morbidity rates associated with severe infections in the critically ill
continue to be a significant issue for the healthcare system. In view of the diverse and …

A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed
for the simultaneous determination of eight β-lactam antibiotics, including ampicillin …

Monitoring of plasma antibiotic drugs is useful for better clinical management in infected
patients, particularly in intensive care units. A simple and sensitive high-performance liquid …