Heart failure remains a major health burden around the world. Despite great progress in
delineation of molecular mechanisms underlying development of disease, standard therapy …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Phosphorus is the main constitutive element of minerals and fat in the body. The process of
mineral formation is defined as mineralization. The minerals in the body are mainly apatite …

Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells;
however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is …

Atrial fibrillation is a significant worldwide contributor to cardiovascular morbidity and
mortality. Few studies have investigated the differences in gene expression between the left …

Cancer is the second leading cause of death worldwide. Despite the availability of
numerous therapeutic options, tumor heterogeneity and chemoresistance have limited the …

Abstract Protein phosphatase 1 (PP1) catalyzes more than half of all phosphoserine/
threonine dephosphorylation reactions in mammalian cells. In vivo PP1 does not exist as a …

Protein phosphatases are important, for example, as functional antagonists of β-adrenergic
stimulation of the mammalian heart. While β-adrenergic stimulations increase the …

Cardiomyocyte contraction relies on precisely regulated intracellular Ca 2+ signaling
through various Ca 2+ channels and transporters. In this article, we will review the …

Regulation of cell-to-cell communication in the heart by the gap junction protein Connexin43
(Cx43) involves modulation of Cx43 phosphorylation state by protein kinases, and …