Principles of regulatory T cell function

S Dikiy, AY Rudensky - Immunity, 2023 - cell.com
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Bile acid metabolites control TH17 and Treg cell differentiation

S Hang, D Paik, L Yao, E Kim, J Trinath, J Lu, S Ha… - Nature, 2019 - nature.com
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated
transformation to generate a large pool of bioactive molecules. Although bile acids are …

The regulation of immune tolerance by FOXP3

L Lu, J Barbi, F Pan - Nature Reviews Immunology, 2017 - nature.com
The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

D Zemmour, R Zilionis, E Kiner, AM Klein, D Mathis… - Nature …, 2018 - nature.com
CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

VDJtools: unifying post-analysis of T cell receptor repertoires

M Shugay, DV Bagaev, MA Turchaninova… - PLoS computational …, 2015 - journals.plos.org
Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

T cell receptor signalling in the control of regulatory T cell differentiation and function

MO Li, AY Rudensky - Nature Reviews Immunology, 2016 - nature.com
Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the
control of self tolerance and inflammatory responses. Recent studies have revealed a …

Stability and function of regulatory T cells expressing the transcription factor T-bet

AG Levine, A Mendoza, S Hemmers, B Moltedo… - Nature, 2017 - nature.com
Adaptive immune responses are tailored to different types of pathogens through
differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T …

Antigen receptor repertoire profiling from RNA-seq data

DA Bolotin, S Poslavsky, AN Davydov, FE Frenkel… - Nature …, 2017 - nature.com
To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result
in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …

CD4 helper and CD8 cytotoxic T cell differentiation

I Taniuchi - Annual review of Immunology, 2018 - annualreviews.org
A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …