The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …

Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

Upper-extremity impairment after stroke remains a major therapeutic challenge and a target
of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we …

Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) disorder that is
associated with functional impairment and accruing disability. There are multiple US Food …

The vagus nerve, the great wanderer, is involved in numerous processes throughout the
body and vagus nerve stimulation (VNS) has the potential to modulate many of these …

The vagus nerve is involved in the autonomic regulation of physiological homeostasis,
through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of …

Cumulative evidence suggests that pyroptosis, a new sort of programmed cell death, is
closely related to cerebral ischemia/reperfusion (I/R) injury. Our previous studies have …

Survival is a fundamental physiological drive, and neural circuits have evolved to prioritize
actions that meet the energy demands of the body. This fine-tuning of goal-directed actions …

Peripheral neuromodulation has emerged as a powerful modality for controlling
physiological functions and treating a variety of medical conditions including chronic pain …