Background: Intrapartum hypoxic events (“birth asphyxia”) may result in stillbirth, neonatal or
postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of …

Background Hypoxic perinatal brain injury is caused by lack of oxygen to baby's brain and
can lead to death or permanent brain damage. However, the effectiveness of therapeutic …

These guidelines on paediatric life support are based on three main principles:(1) the
incidence of critical illness, particularly cardiopulmonary arrest, and injury in children is …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Objective To determine the effectiveness and safety of moderate whole-body hypothermia in
newborns with hypoxic-ischemic encephalopathy born in hospitals with and without …

Adult basic life support and use of automated external defibrillators; 4

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …

Introduction: Hypoxic ischemic encephalopathy (HIE) is the most important reason for
morbidity and mortality in term-born infants. Understanding pathophysiology of the brain …