The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …

Despite a well‐developed and growing body of work in Cu catalysis, the potential of Cu to
serve as a photocatalyst remains underexplored. Reported herein is the first example of …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Morphine and the other alkaloids found in the opium poppy plant still represent the preferred
therapeutic tools to treat severe pain in first aid protocols, as well as chronic pain. The use of …

We here report the first example of the photo-induced preparation of unnatural α-amino
acids and modification of peptides with unactivated alkyl chlorides (iodides) without the …

Spiroketal backbone based diphosphine ligands (SKP) were disclosed to be highly efficient
and enantioselective (94→ 99% ee) in the palladium catalyzed asymmetric allylic amination …

Herein we present the expedient synthesis of endomorphin-1 analogues containing
stereoisomeric β2-homo-Freidinger lactam-like scaffolds ([Amo2] EM), and we discuss …

Opioid peptides are neuromodulators that bind to opioid receptors and reduce pain
sensitivity. Endomorphins are among the most active endogenous opioid peptides, and they …

Mu opioid receptor (MOPr) agonists are thought to produce analgesia via modulation of G-
protein-coupled intracellular signalling pathways whereas the β-arrestin2 pathway is …

Opioids are widely used in the treatment of moderate and severe pain. Nociceptive
stimulation has been reported to potentially promote microglial activation and …