There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Alzheimer's disease is associated with a disruption of amyloid β (Aβ) homeostasis, resulting
in the accumulation and subsequent deposition of Aβ peptides within the brain. The …

Alzheimer's disease (AD) is the most common form of dementia. It is characterized by beta-
amyloid (Aβ) peptide fibrils, which are extracellular depositions of a specific protein, and is …

The renin–angiotensin system (RAS) is an important regulator of blood pressure.
Observational and experimental studies suggest that alterations in blood pressure and …

Peroxisome proliferator activated receptors (PPARs) are well studied for their role of
peripheral metabolism, but they also may be involved in the pathogenesis of various …

Neuroinflammation is involved in the pathology of Alzheimer's disease (AD). Our major focus
was to clarify whether neuroinflammation plays an important role in AD pathogenesis …

Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to provide
neuroprotection in a number of neurodegenerative diseases including Parkinson's disease …

Curing Alzheimer's disease (AD) remains an elusive goal; indeed, it may even prove to be
impossible, given the nature of the disease. Although modulating disease progression is an …

There is an urgent need to improve upon Alzheimer's disease (AD) treatments. Limitations of
existing drugs are that they target specific downstream neurochemical abnormalities while …