Productive cell proliferation involves efficient and accurate splitting of the dividing cell into
two separate entities. This orderly process reflects coordination of diverse cytological events …

In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated
genome has been faithfully replicated and evenly distributed before they complete their …

Cell growth is an essential requirement for cell cycle progression. While it is often held that
growth is independent of cell cycle position, this relationship has not been closely …

The role of Cdc42 and its regulation during cytokinesis is not well understood. Using
biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 …

The differential distribution of the microtubule-organizing centres (MTOCs) that orchestrate
spindle formation during cell division is a fascinating phenomenon originally described in …

Coordination of mitotic exit with chromosome segregation is key for successful mitosis.
Mitotic exit in budding yeast is executed by the mitotic exit network (MEN), which is …

Like many asymmetrically dividing cells, budding yeast segregates mitotic spindle poles
nonrandomly between mother and daughter cells. During metaphase, the spindle …

In budding yeast, the Mitotic Exit Network (MEN) is a signaling pathway known to drive cells
out of mitosis and promote the faithful division of cells. The MEN triggers inactivation of …

The mitotic exit network (MEN) is a spindle pole body (SPB)–associated, GTPase-driven
signaling cascade that controls mitotic exit. The inhibitory Bfa1–Bub2 GTPase-activating …

The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic
cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle …