Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …

COVID-19 is still prevalent around the globe. Although some SARS-CoV-2 vaccines have
been distributed to the population, the shortcomings of vaccines and the continuous …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
challenge the efficacy of approved vaccines, emphasizing the need for updated spike …

Protein expression from stably transfected Chinese hamster ovary (CHO) clones is an
established but time‐consuming method for manufacturing therapeutic recombinant …

People living with HIV-1 (PLWH) exhibit more rapid antibody decline following routine
immunization and elevated baseline chronic inflammation than people without HIV-1 …

Here we show using mass photometry how proline substitutions, commonly used for SARS-
CoV-2 spike stabilisation in vaccine design, directly affects ACE2 receptor interactions via …

ABSTRACT SARS-CoV-2 variants of concern (VOCs) pose a great challenge to viral
prevention and treatment owing to spike (S) protein mutations, which enhance their …

Interactions between the SARS-CoV-2 Spike protein and ACE2 are one of the most
scrutinized reactions of our time. Yet, questions remain as to the impact of glycans on …

Abstract The SARS-CoV-2 virus, belonging to the Coronavirus genus, which poses a threat
to human health worldwide. Current therapies focus on inhibiting viral replication or using …

Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and
trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative …