Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

In the last two or three decades the emphasis on and applications of green chemical
principles, introduced some significant advances in organic synthesis, such as combinatorial …

Multicomponent reactions are flexible reactions for the rapid generation of complex
molecules with often biologically relevant scaffold structures. Combined with the ease of …

Isocyanide (isonitrile) chemistry began in 1859 when Lieke obtained the first compound of
this type. 1 In 1958, isocyanides became generally available by dehydration of formamides …

The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high
structural diversity and molecular complexity. However, the reaction mostly affords a linear …

The isocyanide functionality due to its dichotomy between carbenoid and triple bond
characters, with a nucleophilic and electrophilic terminal carbon, exhibits unusual reactivity …

Reaction rate acceleration using green methods is an intriguing area of research for
chemists. In this regard, water as a “green solvent” plays a crucial role in the acceleration of …

Ugi four-component reactions (U-4CRs) are widely recognized as being highly efficient for
the synthesis of pseudopeptides. However, the products of these reactions are not so …