HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …

Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception,
mood, and a host of cognitive processes. They are considered physiologically safe and do …

Feeding provides substrate for energy metabolism, which is vital to the survival of every
living animal and therefore is subject to intense regulation by brain homeostatic and hedonic …

The neurotransmitter dopamine (DA) has a long association with normal functions such as
motor control, cognition, and reward, as well as a number of syndromes including drug …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area
(VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both …

Dopamine (DA)-containing neurons involved in the regulation of sleep and waking (W) arise
in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNc). The VTA …