Incretin hormones: Their role in health and disease

MA Nauck, JJ Meier - Diabetes, Obesity and Metabolism, 2018 - Wiley Online Library
Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

[HTML][HTML] International consensus on the diagnosis and management of dumping syndrome

E Scarpellini, J Arts, G Karamanolis… - Nature Reviews …, 2020 - nature.com
Dumping syndrome is a common but underdiagnosed complication of gastric and
oesophageal surgery. We initiated a Delphi consensus process with international …

Mechanisms of diabetes improvement following bariatric/metabolic surgery

RL Batterham, DE Cummings - Diabetes care, 2016 - Am Diabetes Assoc
More than 20 years ago, Pories et al. published a seminal article,“Who Would Have Thought
It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus.” …

Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease

DA Sandoval, DA D'Alessio - Physiological reviews, 2015 - journals.physiology.org
The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes

C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Hypoglycemia after gastric bypass surgery: current concepts and controversies

M Salehi, A Vella, T McLaughlin… - The Journal of Clinical …, 2018 - academic.oup.com
Context Hypoglycemia, occurring after bariatric and other forms of upper gastrointestinal
surgery, is increasingly encountered by clinical endocrinologists. The true frequency of this …

Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management

AP Van Beek, M Emous, M Laville, J Tack - Obesity reviews, 2017 - Wiley Online Library
Background Dumping syndrome, a common complication of esophageal, gastric or bariatric
surgery, includes early and late dumping symptoms. Early dumping occurs within 1 h after …

Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline

PE Cryer, L Axelrod, AB Grossman… - The Journal of …, 2009 - academic.oup.com
Objective: The aim is to provide guidelines for the evaluation and management of adults with
hypoglycemic disorders, including those with diabetes mellitus. Evidence: Using the …

The physiology of glucagon-like peptide 1

JJ Holst - Physiological reviews, 2007 - journals.physiology.org
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

[HTML][HTML] Mechanisms in bariatric surgery: gut hormones, diabetes resolution, and weight loss

JJ Holst, S Madsbad, KN Bojsen-Møller… - Surgery for Obesity and …, 2018 - Elsevier
Gastric bypass surgery leads to profound changes in the secretion of gut hormones with
effects on metabolism, appetite, and food intake. Here, we discuss their contributions to the …