[HTML][HTML] Gap junctions
Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
The formation and function of the cardiac conduction system
JH van Weerd, VM Christoffels - Development, 2016 - journals.biologists.com
The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …
conduct the electrical impulse required for the coordinated contraction of the cardiac …
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
The QRS interval, from the beginning of the Q wave to the end of the S wave on an
electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor …
electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor …
Development of the pacemaker tissues of the heart
VM Christoffels, GJ Smits, A Kispert… - Circulation …, 2010 - Am Heart Assoc
Pacemaker and conduction system myocytes play crucial roles in initiating and regulating
the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging …
the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging …
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection
Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …
Myocardial lineage development
SM Evans, D Yelon, FL Conlon, ML Kirby - Circulation research, 2010 - Am Heart Assoc
The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …
lineages, including those of the ventricular and atrial myocardium, and the specialized …
Mechanisms of T-box gene function in the developing heart
F Greulich, C Rudat, A Kispert - Cardiovascular research, 2011 - academic.oup.com
The multi-chambered mammalian heart arises from a simple tube by polar elongation,
myocardial differentiation and morphogenesis. Members of the large family of T-box (Tbx) …
myocardial differentiation and morphogenesis. Members of the large family of T-box (Tbx) …
Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion
Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are
among the most common forms of congenital heart diseases. Normally, heart valve …
among the most common forms of congenital heart diseases. Normally, heart valve …
Transcriptional regulation of the cardiac conduction system
VWW van Eif, HD Devalla, GJJ Boink… - Nature Reviews …, 2018 - nature.com
The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …
system (CCS), a generic term for a collection of different specialized muscular tissues within …
Development of the cardiac conduction system: why are some regions of the heart more arrhythmogenic than others?
VM Christoffels, AFM Moorman - Circulation: Arrhythmia and …, 2009 - Am Heart Assoc
The conduction system of the heart initiates and coordi-nates the electric signal that causes
the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates …
the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates …