Transformer models have emerged as pivotal tools within the realm of drug discovery,
distinguished by their unique architectural features and exceptional performance in …

Synthetic binding proteins (SBPs) represent a pivotal class of artificially engineered proteins,
meticulously crafted to exhibit targeted binding properties and specific functions. Here, the …

Traditional Chinese medicine (TCM) is an ancient medical system distinctive and effective in
treating cancer, depression, coronavirus disease 2019 (COVID-19), and other diseases …

Chemoproteomic probes (CPPs) have been widely considered as powerful molecular
biological tools that enable the highly efficient discovery of both binding proteins and modes …

The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-
based differences in precision oncology. Over 50% of clinically actionable oncology genes …

High-precise modulation of bio-functional proteins related to signaling is crucial in life
sciences and human health. The cutting-edge technology of optogenetics, which combines …

Ferroptosis is a non-apoptotic, iron-dependent regulatory form of cell death characterized by
the accumulation of intracellular reactive oxygen species. In recent years, a large and …

Insomnia, a widespread public health issue, is associated with substantial distress and
daytime functionality impairments and can predispose to depression and cardiovascular …

The escalating costs and high failure rates have decelerated the pace of drug development,
which amplifies the research interests in developing combinatorial/repurposed drugs and …

Protein structure prediction (PSP) remains a central challenge in computational biology due
to its inherent complexity and high dimensionality. While numerous heuristic approaches …