The impact of Parkinson's disease (PD) dementia is substantial and has major functional
and socioeconomic consequences. Early prediction of future cognitive impairment would …

We attempt to correlate the clinical pharmacology of dopamine replacement therapy (DRT)
in Parkinson Disease with known features of striatal dopamine actions. Despite its obvious …

Abstract Purpose of Review: Parkinson disease often spans decades of a patient's lifetime.
Over time, nonmotor symptoms predominate and may limit dopaminergic therapy …

Background Few data exist on the rate of clinical progression for Parkinson's disease (PD)
patients who have entered a late stage of the disease. Objective Study the clinical …

The response to levodopa (LR) is important for managing Parkinson's Disease and is
measured with clinical scales prior to (OFF) and after (ON) levodopa. The aim of this study …

Background: Postural instability is one of the most restricting motor symptoms for patients
with Parkinson's disease (PD). While medication therapy only shows minor effects, it is still …

Background Parkinson's disease (PD), characterized by motor dysfunction and cognitive
decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional …

Background The levodopa challenge test is routinely used in Parkinson disease (PD) to
determine a patient's motor improvement following levodopa administration [levodopa …

Aims To explore the cortical structural reorganization in Parkinson's disease (PD) patients
under chronic dopamine replacement therapy (DRT) in cross‐sectional and longitudinal …

Parkinson's disease (PD) is characterized by decreased dopamine in the basal ganglia that
causes excessive tonic inhibition of the thalamus. This excessive inhibition seems to explain …