Porcine myeloid antimicrobial peptides: a review of the activity and latest advances

S Shi, T Shen, Y Liu, L Chen, C Wang… - Frontiers in Veterinary …, 2021 - frontiersin.org
Traditional antibiotics have made great contributions to human health and animal husbandry
since the discovery of penicillin in 1928, but bacterial resistance and drug residues are …

Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction

N Soundrarajan, S Park, Q Le Van Chanh, H Cho… - Scientific Reports, 2019 - nature.com
Abstract Porcine protegrin-1 (PG-1) is a broad-spectrum antimicrobial peptide (AMP) with
potent antimicrobial activities. We produced recombinant PG-1 and evaluated its cytotoxicity …

Cathelicidins—a rich seam of antimicrobial peptides waiting for exploitation

A Tossi, M Gerdol, A Caporale, S Pacor… - Frontiers in Drug …, 2024 - frontiersin.org
Cathelicidins are a ubiquitous family of host defence antimicrobial peptides in vertebrate
animals. Unlike other antimicrobial peptide families, it is defined by a large and relatively …

Effective Healing of Staphylococcus aureus-Infected Wounds in Pig Cathelicidin Protegrin-1-Overexpressing Transgenic Mice

N Soundrarajan, P Somasundaram, D Kim… - International Journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are promising alternatives to existing treatments for multidrug-
resistant bacteria-infected wounds. Therefore, the effect of protegrin-1 (PG1), a potent …

Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: a high-resolution NMR study

KS Usachev, SV Efimov, OA Kolosova… - Journal of Biomolecular …, 2015 - Springer
A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer
formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore …

Green fluorescent protein as a scaffold for high efficiency production of functional bacteriotoxic proteins in Escherichia coli

N Soundrarajan, H Cho, B Ahn, M Choi, LM Thong… - Scientific Reports, 2016 - nature.com
The availability of simple, robust, and cost-effective methods for the large-scale production of
bacteriotoxic peptides such as antimicrobial peptides (AMPs) is essential for basic and …

[HTML][HTML] Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1

A Javed, T Oedairadjsingh, IS Ludwig, TM Wood… - Molecular …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are a promising alternative to antibiotics in the fight against
multi-drug resistant and immune system-evading bacterial infections. Protegrins are porcine …

Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity

H Jeon, MT Le, B Ahn, H Cho, J Yum, K Hong, JH Kim… - Gene, 2019 - Elsevier
Abstract Proline-arginine-rich (PR)-39 is neutrophil antimicrobial peptide that has potent
antimicrobial activity against a broad spectrum of microorganisms, including bacteria, fungi …

Protegrin-1 Regulates Porcine Granulosa Cell Proliferation via the EGFR-ERK1/2/p38 Signaling Pathway in vitro

B Pan, C Liu, X Zhan, J Li - Frontiers in Physiology, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) are traditionally known to be essential components in host
defense via their broad activities against bacteria, fungi, viruses, and protozoa. Their …

Sequence polymorphisms of PR39 cathelicidins and extensive copy variations in commercial pig breeds

B Ahn, H Jeon, H Cho, S Nagasundarapandian, C Park - Gene, 2022 - Elsevier
Copy number polymorphisms (CNPs) of antimicrobial peptides (AMPs) in livestock can
influence the innate immune response of individuals. We conducted a high-resolution …