Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Obesity is associated with metabolic inflammation and endoplasmic reticulum (ER) stress,
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …

New insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology New
insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology Log in or …

The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances
between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is …