Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Many physiological changes occur in response to endurance exercise in order to adapt to
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies
mostly on tumor size and number. Instead of relying on these factors, we used poor tumor …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

Necrotizing enterocolitis (NEC) is a gastrointestinal disease that results in the exaggerated
intestinal inflammation and injury. Human breast milk–derived exosome (BMEXO) has been …

Background Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA)
metabolism might be involved. The aim of the present study was to clarify the contribution of …

Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD+-dependent protein deacetylase, is
implicated in the pathogenesis of alcoholic liver disease (ALD). However, the role of …

The farnesoid X receptor (FXR, NR1H4) is a bile acid (BA)-activated transcription factor,
which is essential for BA homeostasis. FXR and its hepatic and intestinal target genes, small …

Objective Augmenting nicotinamide adenine dinucleotide (NAD+) metabolism through
dietary provision of NAD+ precursor vitamins translates to improved glucose handling in …