The highly conserved histones in different species seem to represent a very ancient and
universal innate host defense system against microorganisms in the biological world …

Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …

Background & Aims The cancer stem cells (CSCs) have important therapeutic implications
for multi-resistant cancers including hepatocellular carcinoma (HCC). Among the key …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

Short-chain fatty acids (SCFAs) are products of microbial fermentation that are important for
intestinal epithelial health. Here, we describe that SCFAs have rapid and reversible effects …

Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and
play crucial roles in differentiation, proliferation, and cancer. HDAC1 and HDAC2 in …

Chronic obstructive pulmonary disease (COPD), which is caused primarily by cigarette
smoking, is a major health problem worldwide. The progressive decline in lung function that …

Cancer cells frequently exhibit deregulation of coregulatory molecules to drive the process
of growth and metastasis. One such group of ubiquitously expressed coregulators is the …

BACKGROUND: Post-translational modification of proteins by S-nitrosylation serves as a
major mode of signaling in mammalian cells and a growing body of evidence has shown …

BACKGROUND: S-Nitrosothiols are made by nitric oxide synthases and other
metalloproteins. Unlike nitric oxide, S-nitrosothiols are involved in localized, covalent …