Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

CW Schultz, R Preet, T Dhir, DA Dixon… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus

F Yousefi, Z Shabaninejad, S Vakili… - Cell Communication and …, 2020 - Springer
Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading
to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found …

The RNA-binding protein HuR in human cancer: a friend or foe?

X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR

B Liu, G Yang, X Wang, J Liu, Z Lu… - Journal of Cellular …, 2020 - Wiley Online Library
In recent years, an increasing number of circular RNAs (circRNAs) have been discovered in
hepatocellular carcinoma (HCC). However, the functions of most circRNAs require further …

RNA-binding proteins: Emerging therapeutics for vascular dysfunction

VA Cornelius, H Naderi-Meshkin, S Kelaini, A Margariti - Cells, 2022 - mdpi.com
Vascular diseases account for a significant number of deaths worldwide, with cardiovascular
diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden …

Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts

S Dubey, PK Dubey, CS Umeshappa… - Journal of cellular …, 2022 - Wiley Online Library
Pathological fibrosis contributes to progression of various diseases, for which the
therapeutic options are limited. Idiopathic pulmonary fibrosis (IPF) is one such progressive …

Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts

X Wu, R Ramesh, J Wang, Y Zheng… - Journal of medicinal …, 2023 - ACS Publications
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …

[HTML][HTML] Single-cell analysis reveals lysyl oxidase (Lox)+ fibroblast subset involved in cardiac fibrosis of diabetic mice

H Li, X Zhu, X Cao, Y Lu, J Zhou, X Zhang - Journal of advanced research, 2023 - Elsevier
Introduction Myocardial fibrosis and cardiac dysfunction are the main characteristics of
diabetic heart disease. However, the molecular mechanisms underlying diabetic myocardial …