Growth and development can be investigated using readily observable demographic factors
such as weight and age. Size is the primary covariate and can be referenced to a 70-kg …

The pharmacokinetic behavior of medicines used in humans follows largely predictable
patterns across the human age range from premature babies to elderly adults. Most of the …

Growth and development are two major aspects of children not readily apparent in adults.
Clearance in the paediatric population should be investigated using models that describe …

This study pools published data to describe the increase in glomerular filtration rate (GFR)
from very premature neonates to young adults. The data comprises measured GFR (using …

Despite nearly five decades of clinical use, vancomycin has retained a significant and
uncontested niche in the antibacterial arsenal because of its consistent activity against …

National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus
(MRSA) infections recommend targeting a vancomycin 24-h area under the concentration …

OBJECTIVE: In very preterm infants, there is a high risk for impaired kidney function;
therefore, access to normal ranges of glomerular filtration rate (GFR) for age and definition of …

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling has elucidated aspects of
developmental pharmacology of value to the anesthetic community. The increasing …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Although it has been on the market for over a decade, confusion remains regarding the
pharmacokinetics (PK) and optimal dosing of palivizumab, a humanized IgG1κ monoclonal …