[HTML][HTML] Pathophysiology and treatment of cerebral edema in traumatic brain injury

RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Guidelines for the management of pediatric severe traumatic brain injury: update of the brain trauma foundation guidelines

PM Kochanek, RC Tasker, N Carney… - Pediatric Critical Care …, 2019 - journals.lww.com
Any opinions, findings, and conclusions or recommendations expressed in this material are
those of the authors and do not necessarily reflect the views of the US Army Contracting …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain

GC Ferreira, MC McKenna - Neurochemical research, 2017 - Springer
Abstract l-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for
degradation by β-oxidation. Treatment with l-carnitine can ameliorate metabolic imbalances …

[HTML][HTML] An overview of management of intracranial hypertension in the intensive care unit

T Schizodimos, V Soulountsi, C Iasonidou… - Journal of …, 2020 - Springer
Intracranial hypertension (IH) is a clinical condition commonly encountered in the intensive
care unit, which requires immediate treatment. The maintenance of normal intracranial …

[HTML][HTML] Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

M Cruz-Haces, J Tang, G Acosta, J Fernandez… - Translational …, 2017 - Springer
Traumatic brain injury is among the most common causes of death and disability in youth
and young adults. In addition to the acute risk of morbidity with moderate to severe injuries …

[HTML][HTML] Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

O Albayram, A Kondo, R Mannix, C Smith… - Nature …, 2017 - nature.com
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and
associated with the development of chronic traumatic encephalopathy (CTE) and …

[HTML][HTML] Long non-coding RNA in CNS injuries: a new target for therapeutic intervention

L Zhang, H Wang - Molecular Therapy-Nucleic Acids, 2019 - cell.com
CNS injuries, such as traumatic brain injury (TBI), subarachnoid hemorrhage (SAH),
intracerebral hemorrhage (ICH), and cerebral ischemic stroke, are important causes of death …

Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders

YN Paudel, E Angelopoulou, B Semple… - ACS chemical …, 2020 - ACS Publications
Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza
glabra, is a traditional medicine possessing a plethora of pharmacological anti-inflammatory …

Mitochondrial dysfunctioning and neuroinflammation: Recent highlights on the possible mechanisms involved in Traumatic Brain Injury

DK Sahel, M Kaira, K Raj, S Sharma, S Singh - Neuroscience letters, 2019 - Elsevier
Traumatic brain injury (TBI) is the injury to the vasculature of brain while trauma caused by
physical, chemical and biological stimuli. TBI is the leading cause of mortality and morbidity …