Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury
to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm …

Patients with severe lung injury usually have a high respiratory drive, resulting in intense
inspiratory effort that may even worsen lung damage by several mechanisms gathered …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated
with poor clinical outcomes. Although the importance and impact of lung-protective …

Methods We conducted a retrospective, bicenter study at the Sainte Anne Military Hospital
and the Marseille University North Hospital. This study enrolled critically ill patients with mild …

Background: Monitoring and controlling lung stress and diaphragm effort has been
hypothesized to limit lung injury and diaphragm injury. The occluded inspiratory airway …

Advanced respiratory monitoring involves several mini-or noninvasive tools, applicable at
bedside, focused on assessing lung aeration and morphology, lung recruitment and …

There is a well-recognised importance for personalising mechanical ventilation settings to
protect the lungs and the diaphragm for each individual patient. Measurement of …

Background There is very limited evidence identifying factors that increase respiratory drive
in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot …

Abstract Treatment of respiratory failure has improved dramatically since the polio epidemic
in the 1950s with the use of invasive techniques for respiratory support: mechanical …

OBJECTIVES: In mechanically ventilated patients, deep sedation is often assumed to induce
“respirolysis,” that is, lyse spontaneous respiratory effort, whereas light sedation is often …