Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease
involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease,
compromising both native and transplanted kidneys. Treatment is limited because of a …

Significance: Regulation of cell adhesions during tissue repair is fundamentally important for
cell migration, proliferation, and protein production. All cells interact with extracellular matrix …

The response of innate immune cells to growth factors, immune complexes, extracellular
matrix proteins, cytokines, pathogens, cellular damage, and many other stimuli is regulated …

Tumors often overcome the cytotoxic effects of chemotherapy through either acquired or
environment-mediated drug resistance. In addition, signals from the microenvironment …

Adhesion of breast cancer cells is supported by various integrins. Cell adhesion is critical for
maintenance of both three-dimensional and normal function of these tissues. Several …

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type
plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is …